منابع مشابه
In Silico Toxicology – Non-Testing Methods
In silico toxicology in its broadest sense means "anything that we can do with a computer in toxicology." Many different types of in silico methods have been developed to characterize and predict toxic outcomes in humans and environment. The term non-testing methods denote grouping approaches, structure-activity relationship, and expert systems. These methods are already used for regulatory pur...
متن کاملToxicology is IN: in silico, in vitro, integrated testing strategy.
for hazard identification and characterization and/or safety assessment of chemicals based on multiple information sources, which integrates and weighs all relevant existing data, guiding the targeted generation of new data to inform regulatory decision-making about potential hazards or risks. Such an approach has already been successfully applied in the ECVAM Skin Sensitisation Project and has...
متن کاملFood for thought ... on in silico methods in toxicology.
this series of articles has already addressed in vitro and in vivo tools (Hartung, 2007; Hartung, 2008b). With this contribution addressing computational toxicology we now try to complete considerations on the main methodological approaches in toxicology. However, we do still plan to address specific aspects, such as endpoints (omics, image technologies), high-throughput testing or physiology-b...
متن کاملExperimental toxicology in silico.
A review on applicability of in silico methods for toxicity testing by calculation for regulatory purposes, their survey and background of QSAR (Quantitative Structure-Activity Relationships) analysis are presented.
متن کاملIn silico methods - Computational alternatives to animal testing.
ALTEX 35(1), 2018 126 and Refinement of animal testing), their beginnings, impact and development over the years as well as the introduction of additional Rs such as Responsibility, Rehabilitation or Remember. Topics and strategies such as the use of “lower” animals, fewer animals, maximizing study outcome, animal sharing and welfare were discussed. Prof. Schneider closed his talk leading over ...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2011
ISSN: 1663-9812
DOI: 10.3389/fphar.2011.00033